Metastable solid forms play a crucial role in improving the solubility of poorly water soluble drugs. Amorphous solid dispersions have been established as a promising method to stabilise amorphous forms. Embedding in a matrix and combination with specially selected additives prevents crystallisation. In addition, particle coatings or encapsulations can be used to protect the surfaces of crystalline metastable solid forms and prevent phase transformations. In this way, metastable solid forms can be effectively used in pharmaceuticals.
