B cells are a pillar of the immune system due to their unique capacity to produce antibodies. Yet, these lymphocytes are also major contributors to numerous pathologies, such as autoimmunity and cancers, notably due to alterations in their survival, activation or formation. In addition, remodeling of B cell development and functionality participate in the suboptimal effectiveness of immune responses during aging. We are investigating the molecular processes controlling the expression of genetic programs involved in various aspects of B cell physiology. In particular, we explore how aging impacts these regulatory mechanisms, at the transcriptional and translational levels. The gained knowledge should help us to design approaches to improve B cell responses, hence antibody production, in old individuals.

Publications:

ORCID