SFB-F44 - Cell signaling in chronic CNS disorders

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Project 04:
Functional read-outs and novel interventional targets in a transgenic MSA model

Gregor Wenning and Nadia Stefanova

Multiple system atrophy (MSA) is a fatal orphan disease that shares numerous features with PD including Parkinsonism and α-syuclein (α-syn) associated neurodegeneration. This group successfully established numerous rodent MSA models for pathogenic target identification and preclinical drug screening. Here we will characterize non-motor read-outs in transgenic (tg) MSA mice and also address the role of L-ype Ca²⁺ channels and epigenetic signalling changes in MSA-associated neurodegeneration.