Research
Current research activities at the CMBI encompass investigations into the structure and dynamics of biological macromolecules at atomic resolution, the molecular basis of physiological and pathophysiological processes and their modulation by natural or synthetic products, cellular function and cell-cell communication, and development of whole organisms.
Research topics:
- Biomolecular mass spectrometry (Breuker, Müller)
- Proteomics, metabolomics, phytomics (Huck)
- Inelastic interaction of low energy electrons with molecules of biological relevance (Denifl)
- Development of theoretical and computational methods describing molecular interactions in chemical and biological systems (Liedl)
- NMR spectroscopy, food allergens, intrinsically denatured proteins, RNA chaperones (Tollinger)
- Synthesis, structure, and function of chemically modified RNA (Micura)
- NMR spectroscopy, structural dynamics of nucleic acids, RNA chemistry (Kreutz)
- Method development and chemical synthesis of bioactive molecules (Magauer)
- Regulation of cell function by protein modification (Schneider)
- Oncogenic transcription factors and their cellular targets (Stefan, Hartl)
- Analysis, bioactivity, and target deconvolution of secondary metabolites (Ganzera, Moser)
- Development of potential drugs interacting with opioid receptors (Spetea)
- Lipid signaling in cancer, inflammation and homeostasis as target for natural products (Koeberle)
- Computational design of small molecule and gene therapies and investigation of drug resistance mechanisms (Kaserer)
- Ion channels as new drug targets and the neuropathological basis of anxiety disorders (Striessnig, Singewald)
- Ion channels in retinal physiology, diseases and pharmacotherapy (Koschak)
- Ion channels structure-function and their role in hormone release (Tuluc)
- Cell ion and volume homeostasis and metabolic activity (Schwerte, Sandbichler)
- Trace element homeostasis in animal cells (Dallinger)
- Molecular and genetic control of vertebrate development (Meyer, Kimmel)
- Stem cell differentiation, regeneration and bioadhesion of basal Metazoa (Hobmayer, Ladurner)
- Stem cell biology, cellular reprogramming & regeneration (Edenhofer)
- Environmental stress response – molecular, physiological, and metabolic mechanisms (Höckner)
- Biology of aging, mitochondrial physiology (Jansen-Dürr)
- Stress metabolites and signalling pathways in plants (Kranner)
- Obesity/weight loss research, adipose tissue biology, stem cell proliferation, differentiation and aging (Zwerschke)