Assoc.-Prof. Priv.-Doz. M.Sc, Ph.D Petronel Tuluc
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| Molecular Endocrinology Group CavX PhD Program 'Calcium channels in excitable cells' Short CV |
Contact
Leopold Franzens University of Innsbruck
Institute of Pharmacy - Department for Pharmacology and Toxicology
Center of Chemistry and Biomedicine
Innrain 80-82, A-6020 Innsbruck, Austria
Phone: +43-(0) 512-507-58805
E-mail: Petronel.Tuluc@uibk.ac.at
Webpage: https://www.uibk.ac.at/pharmazie/pharmakologie/tuluc-gruppe/tuluc-gruppe.html
Graduate Program: https://cavx.at
Research network: https://www.uibk.ac.at/cmbi/
ORCID No.: 0000-0003-3660-6138
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| Education |
| 2018 |
| 2004 - 2008 |
| 2001 - 2003 |
| 2001 - 2002 |
| 1997 - 2001 |
| Academic career history |
| 2018-presently |
| 2013 - 2018 |
| 2010 - 2013 |
| 2008 - 2010 |
| Main research areas |
| Role of CaV calcium channels in endocrine cells hormone release. Molecular mechanism of insulin release in health and Diabetes Mellitus. Structure and function of CaV channels and their voltage sensing mechanism. Computer modelling of membrane excitability. Skeletal and cardiac muscle excitation-contraction coupling |
| Past research funding |
| 2023-2027 (€1.441.421) |
| 2023-2027 (€191.456) |
| 2022-2026 (€408.604) |
| 2019-2022 (€405.026) |
| 2018-2022 (EUR 170.670) |
| 2014-2016 (EUR 19.804) |
| 2012-2014 (EUR 10.000) |
| 2011-2015 (EUR 399.913) |
| 2008-2010 (EUR 125.923) |
| Total =3.002.147€ Own part = 1.657.211€ |
| Peer review activities |
| Ad hoc referee for: Diabetes, Nature Communications, Channels, Biophysical Journal, European Journal of Neuroscience, European Journal of Physiology, Translational Psychiatry, PLOS one, Scientific Reports, Cell Reports, J. Gen. Physiology, Toxicology in Vitro, Hungarian Scientific Research Fund, Medical Research Fund-UK, Marsden Fund-NZ. |
| Publications |
| 40 (32 original, 8 reviews/book chapters). Citations 2268, h-index=25, i10 index 32. Full publication list here. |
| Most relevant publications: |
| Jacobo-Piqueras, N., Theiner, T., Geisler, S. M. & Tuluc, P. Molecular mechanism responsible for sex differences in electrical activity of mouse pancreatic beta cells. JCI Insight 9, doi:10.1172/jci.insight.171609 (2024) https://www.ncbi.nlm.nih.gov/pubmed/38358819 |
| Ortner, N. J., Sah, A., Paradiso, E., Shin, J., Stojanovic, S., Hammer, N., Haritonova, M., Hofer, N. T., Marcantoni, A., Guarina, L., Tuluc, P., Theiner, T., Pitterl, F., Ebner, K., Oberacher, H., Carbone, E., Stefanova, N., Ferraguti, F., Singewald, N., Roeper, J. & Striessnig, J. The human channel gating-modifying A749G CACNA1D (Cav1.3) variant induces a neurodevelopmental syndrome-like phenotype in mice. JCI Insight 8, doi:10.1172/jci.insight.162100 (2023) https://www.ncbi.nlm.nih.gov/pubmed/37698939 |
| Fernandez-Quintero, M. L., El Ghaleb, Y., Tuluc, P., Campiglio, M., Liedl, K. R. & Flucher, B. E. Structural determinants of voltage-gating properties in calcium channels. Elife 10, doi:10.7554/eLife.64087 (2021) https://www.ncbi.nlm.nih.gov/pubmed/33783354 |
| El Ghaleb, Y., Schneeberger, P. E., Fernandez-Quintero, M. L., Geisler, S. M., Pelizzari, S., Polstra, A. M., van Hagen, J. M., Denecke, J., Campiglio, M., Liedl, K. R., Stevens, C. A., Person, R. E., Rentas, S., Marsh, E. D., Conlin, L. K., Tuluc, P., Kutsche, K. & Flucher, B. E. CACNA1I gain-of-function mutations differentially affect channel gating and cause neurodevelopmental disorders. Brain 144, 2092-2106, doi:10.1093/brain/awab101 (2021) https://www.ncbi.nlm.nih.gov/pubmed/33704440 |
| Hofer, N. T., Tuluc, P., Ortner, N. J., Nikonishyna, Y. V., Fernandes-Quintero, M. L., Liedl, K. R., Flucher, B. E., Cox, H. & Striessnig, J. Biophysical classification of a CACNA1D de novo mutation as a high-risk mutation for a severe neurodevelopmental disorder. Mol Autism 11, 4, doi:10.1186/s13229-019-0310-4 (2020) https://www.ncbi.nlm.nih.gov/pubmed/31921405 |
| Monteleone, S., Lieb, A., Pinggera, A., Negro, G., Fuchs, J. E., Hofer, F., Striessnig, J., Tuluc, P. & Liedl, K. R. Mechanisms Responsible for omega-Pore Currents in Ca(v) Calcium Channel Voltage-Sensing Domains. Biophys J 113, 1485-1495, doi:10.1016/j.bpj.2017.08.010 (2017) https://www.ncbi.nlm.nih.gov/pubmed/28978442 |
| Mastrolia, V., Flucher, S. M., Obermair, G. J., Drach, M., Hofer, H., Renstrom, E., Schwartz, A., Striessnig, J., Flucher, B. E. & Tuluc, P. Loss of alpha(2)delta-1 Calcium Channel Subunit Function Increases the Susceptibility for Diabetes. Diabetes 66, 897-907, doi:10.2337/db16-0336 (2017) https://www.ncbi.nlm.nih.gov/pubmed/28115397 |
| Tuluc, P., Yarov-Yarovoy, V., Benedetti, B. & Flucher, B. E. Molecular Interactions in the Voltage Sensor Controlling Gating Properties of CaV Calcium Channels. Structure 24, 261-271, doi:10.1016/j.str.2015.11.011 (2016) https://www.ncbi.nlm.nih.gov/pubmed/26749442 |
| Ortner, N. J., Bock, G., Vandael, D. H., Mauersberger, R., Draheim, H. J., Gust, R., Carbone, E., Tuluc, P. & Striessnig, J. Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators. Nat Commun 5, 3897, doi:10.1038/ncomms4897 (2014) https://www.ncbi.nlm.nih.gov/pubmed/24941892 |
| Azizan, E. A., Poulsen, H., Tuluc, P., Zhou, J., Clausen, M. V., Lieb, A., Maniero, C., Garg, S., Bochukova, E. G., Zhao, W., Shaikh, L. H., Brighton, C. A., Teo, A. E., Davenport, A. P., Dekkers, T., Tops, B., Kusters, B., Ceral, J., Yeo, G. S., Neogi, S. G., McFarlane, I., Rosenfeld, N., Marass, F., Hadfield, J., Margas, W., Chaggar, K., Solar, M., Deinum, J., Dolphin, A. C., Farooqi, I. S., Striessnig, J., Nissen, P. & Brown, M. J. Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nat Genet 45, 1055-1060, doi:10.1038/ng.2716 (2013) https://www.ncbi.nlm.nih.gov/pubmed/23913004 |
| Tuluc, P., Molenda, N., Schlick, B., Obermair, G. J., Flucher, B. E. & Jurkat-Rott, K. A CaV1.1 Ca2+ channel splice variant with high conductance and voltage-sensitivity alters EC coupling in developing skeletal muscle. Biophys J 96, 35-44, doi:10.1016/j.bpj.2008.09.027 (2009) https://www.ncbi.nlm.nih.gov/pubmed/19134469 |
| Tuluc, P., Kern, G., Obermair, G. J. & Flucher, B. E. Computer modeling of siRNA knockdown effects indicates an essential role of the Ca2+ channel alpha2delta-1 subunit in cardiac excitation-contraction coupling. Proc Natl Acad Sci U S A 104, 11091-11096, doi:10.1073/pnas.0700577104 (2007) https://www.ncbi.nlm.nih.gov/pubmed/17563358 |
| 10 most important scientific/scholarly research achievements apart from academic publications |
| 2001: Erasmus Scholarsip – Montpellier, France 2007: Molecular Cell Biology and Oncology doctoral program award fellowship 2008: Research Fellowship of the Medical University of Innsbruck 2010: Early investigator award from The American Biophysical Society and the Biophysical Society of China 2013: International calcium channel symposium, Symposium Speaker (March 24-29, Krabi Thailand) 2018: 3rd European Calcium Channel Conference, Speaker, May 9-12, Alpbach, Austria 2021: Austrian Neuroscience association meeting, Symposium Speaker, September 28-20, Salzburg, Austria 2022: 21st International Symposium on Chromaffin cell Biology, Symposium Speaker (7-12 July, Hamburg, Germany) 2023: Speaker of the FWF-funded CaVX PhD program International calcium channel meeting, Symposium Speaker (February 25-March 1, Boracay Philippines) |
| Press releases |
| 2024: Diabetes und Geschlecht DE/EN 2024: Collaboratively exploring vital calcium channels DE/EN 2021: Kalziumkanal: Krankheitsgen für neuronale Entwicklungsstörung EN/DE 2018: Kanalarbeiter im Labor EN/DE |
| Memberships |
| American Biophysical Society European Association for the Stufy of Diabetes Austrian Biophysical Society Center for Molecular Biosciences Innsbruck |