2924-12-03

Unified Divergent Total Synthesis of Discorhabdin B, H, K, and Aleutianamine via the Late-Stage Oxidative N,S-Acetal Formation

M. Shimomura, K. Ide, J. Sakata, H. Tokuyama, J. Am. Chem. Soc. 2023, 33, 18233–18239.

2024-11-26

Total Synthesis of Icumazole A Using a Modified Cadiot–Chodkiewicz Coupling

J. Buntine, S. Dasgupta, K. Dorney, O. Rubinstein, M. Salimimarand, J. M. White, M. A. Rizzacasa, Org. Lett. 2024, 26, 1062–1066.

2024-11-19

Catalytic Asymmetric Total Synthesis of (−)-Garryine via anEnantioselective Heck Reaction

C. Li, F. Lu, Y. Cai, C. Zhang, Y. Shao, Y. Zhang, X.-Y. Liu, Y. Qin, J. Am. Chem. Soc. 2024, 146, 1081−1088.

2024-11-12

Total Synthesis of (±)-Aspidophylline

W. Ren, Q. Wang, J. Zhu, Angew. Chem. Int. Ed. 2014, 53, 1818–1821.

2024-11-05

Total Synthesis of the Allenic Macrolide (+)-Archangiumide

J. L. Sutro, A. Fürstner, J. Am. Chem. Soc. 2024, 146, 2345–2350.

2024-10-29

Enantioselective Total Synthesis of (+)-Pedrolide

M. Fadel, E. M. Carreira, J. Am. Chem. Soc. 2023, 145, 15, 8332–8337

2024-10-22

Total Synthesis of Mollanol A

Y. Wang, R. Zhao, M. Yang, J. Am. Chem. Soc. 2022, 144, 15033–15037.

2024-10-15

Enantioselective Total Synthesis of (+)-Salvileucalin B

S. Levin, R. R. Nani, S. E. Reisman, J. Am. Chem. Soc. 2011, 133, 774–776.

2024-10-08

Synthesis of (–)-Picrotoxinin by Late-Stage Strong Bond Activation

S. W. M. Crossley, G. Tong, M. J. Lambrecht, H. E. Burdge, R. A. Shenvi, J. Am. Chem. Soc. 2020, 142, 11376–11381.

2024-10-01

Total Synthesis of (+)-Alstilobanine C

G. Li, N. Gaeng, C. Piemontesi, Q. Wang, J. Zhu, Angew. Chem., Int. Ed. 2021, 60, 12392.

2024-09-25

Asymmetric Total Synthesis of Clionastatins A and B

W. Ju, X. Wang, H. Tian, J. Gui, J. Am. Chem. Soc. 2021, 143, 13016–13021.

2024-09-18

Enantioselective Total Synthesis of (−)-Artatrovirenol A

R. Lavernhe, P. Domke, Q. Wang, J. Zhu, J. Am. Chem. Soc. 2023, 145, 24408−24415.

Total Synthesis of (–)-Retigeranic Acid A: A Reductive Skeletal Rearrangement Strategy

D. Sun, R. Chen, D. Tang, Q. Xia, Y. Zhao, C. Liu, H. Ding, J. Am. Chem. Soc. 2023, 145, 11927–11932.

Enantioselective Total Synthesis of (−)-Hunterine A Enabled by a Desymmetrization/Rearrangement Strategy

E. F. Hicks, K. Inoue, B. M. Stoltz, J. Am. Chem. Soc. 2024, 146, 4340–4345.

Total Synthesis of (–)-Okilactomycin

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Total Synthesis of Chalcitrin

M. Yang, F. Yin, H. Fujino, S. A. Synder, J. Am. Chem. Soc. 2019, 141, 4515–4520.

Allenamide-Initiated Cascade [2+2+2] Annulation Enabling the Divergent Total Synthesis of (–)-Deoxoapodine, (–)-Kopsifoline D and (±)-Melotenine

L.-P. Zhao, P.-J. Li, L. Wang, Angew. Chem. Int. Ed. 2022, 61, e202207360.

Total Synthesis of atropurpuran

J. Gong, H. Chen, X.-Y. Liu, Z.-X. Wang, W. Nie, Y. Qin, Nat. Commun. 2016, 7, 12183.

Total Synthesis of Aspidophytine

K. C. Nicolaou, S. M. Dalby, U. Majumder, J. Am. Chem. Soc. 2008, 130, 14942–14943.

Divergent Synthesis of 17-nor-Cephalotane Diterpenoids through Developed Ynol-diene Cyclization

Z. Sun, X. Shu, F. Ma, A. Li, Y. Li, S. Jin, Y. Wang, H. Xiangdong, H. Angew. Chem. Int. Ed. 2024, e202407757.

Convergent and Efficient Total Synthesis of (+)-Heilonine enabled by C–H Functionalizations

Y. Jin, S. Hok, J. Bacsa, M. Dai, J. Am. Chem. Soc. 2024, 146, 1825-1831.

Total Synthesis of (–)-Strempeliopine

X. Zeng, D. L. Boger, J. Am. Chem. Soc. 2021, 143, 12412–12417.

A Convergent Total Synthesis of (+)-Ineleganolide

B. M. Gross, S. Han, S. C. Virgil, B. M. Stoltz, J. Am. Chem. Soc. 2023, 145, 7763-7767.

Enantioselective Total Synthesis of (—)-Himalensine A via a Palladium and 4-Hydroxyproline Cocatalyzed Desymmetrization of Vinyl-bromide-tethered Cyclohexanones.

R. Kučera, S. R. Ellis, K. Yamazakl, J. H. Cook, N. Chekshin, K. E. Christensen, T. A. Hamlin, D. J. Dixon, J. Am. Chem. Soc. 2023, 145, 5422-5430.

Total Synthesis of Five Thapsigargins: Guaianolide Natural Products Exhibiting Sub-Nanomolar SERCA Inhibition

S. P. Andrews, M. Ball, F. Wierschem, E. Cleator, S. Oliver, K. Högenauer, O. Simic, A. Antonello, U. Hünger, M. D. Smith, S. V. Ley, Chem. Eur. J. 2007, 13, 5688–5712.

Total Synthesis of ( )-Lepadiformine A Utilizing Hg(OTf)2-Catalyzed
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Concise Total Synthesis of (-)-Bipolarolide

S. Sun, Q. Wei, Y. Liu, Z. Lu, J. Am. Chem. Soc. 2024, ASAP.

Total Synthesis of Aleutianamine

H. Yu, Z. P. Sercel, S. P. Rezgui, J. Farhi, S. C. Virgil, B. M. Stoltz, J. Am. Chem. Soc. 2023, 145, 25533-25537.

Total Synthesis of (−)-Batrachotoxin Enabled by a Pd/Ag-Promoted Suzuki–Miyaura Coupling Reaction

Y. Watanabe, H. Morozumi, H. Mutoh, K. Hagiwara, M. Inoue, Angew. Chem. Int. Ed. 2023, 62, e202309688.

Total Synthesis of Putative Melognine

Y. Irie, S. Yokoshima, J. Am. Chem. Soc. 2024, 146, 9526–9531.

Total Synthesis of Resiniferatoxin

V. H. Vasilev, L. Spessert, K. Yu, T. J. Maimone, J. Am. Chem. Soc. 2022, 144, 16332–16337.

Total Synthesis of (–)-Conidiogenone B

B. Xu, W. Xun, S. Su, H. Zhai, Angew. Chem. Int. Ed. 2020, 59, 16475–16479.

Asymmetric Total Synthesis of (2R)-Hydroxynorneomajucin, a Norsesquiterpene from Illicium jiadifengpi

C.J Dooley III, S. D. Rychnovsky, Org. Lett. 2022, 24, 3411–3415.

Asymmetric Total Synthesis of Propindilactone G

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Total Synthesis of (±)-Isostemofoline

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Platinum- and Gold-Catalyzed Rearrangement Reactions of Propargyl Acetates: Total Syntheses of (−)-a-Cubebene, (−)-Cubebol, Sesquicarene and Related Terpenes

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Divergent Asymmetric Total Synthesis of (–)-Voacafricines A and B

R. Andres, Q. Wang, J. Zhu, Angew. Chem. Int. Ed. 2023, 62, e202301517.

Total Synthesis of (±)-Gelsemine

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Total Synthesis, Relay Synthesis, and Structural Confirmation of the C18-Norditerpenoid Alkaloid Neofinaconitine

Y. Shi, J. T. Wilmot, L. U. Nordstrøm, D.S. Tan, D. Y. Gin, J. Am. Chem. Soc. 2013, 135, 14313–14320.

Total Synthesis of Kamebanin

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Enantioselective Syntheses of Wickerols A and B

J. Chung, J. S. Capani, M. Göhl, P. C. Roosen, C. D. Vanderwal, J. Am. Chem. Soc. 2023, 145, 6486–6497.

Synthesis of Pleuromutilin

N. J. Foy, S. V. Pronin, J. Am. Chem. Soc. 2022, 144, 10174–10179.

A Concise Total Synthesis of (+)-Waihoensene Guided by Quaternary Center Analysis

C. Peng, P. Arya, Z. Zhou, S. P. Snyder, Angew. Chem. Int. Ed. 2020, 59, 13521–13525.

Catalysis-Enabled 13-Step Total Synthesis of (−)-Peyssonnoside A

B. Xu, C. Liu, M. Dai, J. Am. Chem. Soc. 2022, 144, 19700–19703.

Streamlined Total Synthesis of Uncialamycin and Its Application to the Synthesis of Designed Analogues for Biological Investigations

K. C. Nicolaou, Y. Wang, M. Lu, D. Mandal, M. R. Pattanayak, R. Yu, A. A. Shah, J. S. Chen, H. Zhang, J. J. Crawford, L. Pasunoori, Y. B. Poudel, N. S. Chowdari, C. Pan, A. Nazeer, S. Gangwar, G. Vite, E. N. Pitsinos, J. Am. Chem. Soc. 2016, 138, 8235–8246.

Total Synthesis of Strychnine

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Total Synthesis of Scabrolide A and Yonarolide

R. Serrano, Y. D. Boyko, L. W. Hernandez, A. Lotuzas, D. Sarlah, J. Am. Chem. Soc. 2023, 145, 8805–8809.

Enantioselective Total Synthesis of (+)-Dihydro-β-erythroidine

S. Clementson, M. Jessing, H. Pedersen, P. Vital, J. L. Kristensen, J. Am. Chem. Soc. 2019, 141, 8783−8786.

Bent π-Conjugation within a Macrocycle: Asymmetric Total Syntheses of Spirohexenolides A and B

L.-D. Guo, Y. Wu, X. Xu, Z. Lin, R. Tong, Angew. Chem. Int. Ed. 2023, e202316259.

Site-Specific Photochemical Desaturation Enables Divergent Syntheses of Illicium Sesquiterpenes

Y. Shen, L. Li, X. Xiao, S. Yang, Y. Hua, Y. Wang, Y.-W. Zhang, Y. Zhang, J. Am. Chem. Soc. 2021, 143, 3256–3263.

Total Synthesis of (+)-Fendleridine (Aspidoalbidine) and (+)-1-Acetylaspidoalbidine

E.L. Campbell, .M. Zuhl, C.M. Liu, D.L. Boger, J. Am. Chem. Soc. 2010, 132, 3009–3012.

Enantioselective Total Syntheses of the Cephalotaxus Alkaloids (−)-Fortuneicyclidins A and B and (−)-Cephalotine B

P.-Z. Sheng, Z.-B. Ni, L.-L. Li, K. Wei, H. Zhang, Y.-R. Yang, Org. Lett. 2023, 25, 7464–7469

Enantioselective Total Synthesis of (-)-Maoecrystal V

C. Zheng, I. Dubovyk, K. E. Lazarski, R. E. Thomson, J. Am. Chem. Soc. 2014, 136, 17750–17756

Asymmetric Synthesis of Cyclopamine, a Hedgehog (Hh) Signaling Pathway Inhibitor
A. Shao, W. Liu, M. Liu, H. He, Q.-L. Zhou, S.-F. Zhu, S. Gao, J. Am. Chem. Soc. 2023, DOI:10.1021/jacs.3c10362

Total Synthesis of (-)-Nummularine F
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Total Synthesis of (+)-Gracilamine Based on an Oxidative Phenolic Coupling Reaction and Determination of its Absolute Configuration

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Total Synthesis of (+)-Aberrarone

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Enantioselective Total Synthesis of (−)-Pavidolide B

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Synthesis of ent-Ketorfanol via a C-H Alkenylation/Torquoselective 6𝝿 Electrocyclization Cascade

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Total Synthesis of the Isodon Diterpene Sculponeatin N

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Total Synthesis of Rubriflordilactone B

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Total Synthesis of Isorosthin L and Isodenolin I

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Scalable Total Synthesis of Portimine A and B Reveals the Basis of Their Potent and Selective Anti-cancer Acitvity

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Total Synthesis of Lyconesidine B

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Enantioselective Total Synthesis of (+)-Stephadiamine

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Asymmetric Total Synthesis of Illisimonin A

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Total Synthesis of (+)-Fawcettidine

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Oxidative Entry into the Illicium Sesquiterpenes: Enantiospecific: Synthesis of (+)-Pseudoanisatin

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Total Synthesis of (−)-Sinulariadiolide. A Transannular Approach

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Total Synthesis of Andirolide N via 8-a-Hydroxycarapin

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Enantioselective Total Synthesis of (-)-Limaspermidine and (-)-Kopsinine by a Nitroaryl Transfer Cascade Strategy

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Total Synthesis of (±)-Waihoensene

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Asymmetric Total Synthesis of (+)-6-epi-Castanospermine by the Stereoselective Formation of asyn,anti Acetylenic 2-Amino-1,3-diol Stereotriad

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A Concise Synthesis of Pleurotin Enabled by a Nontraditional C-H Epimerization

J. F. Hoskin, E. J. Sorensen, J. Am. Chem. Soc. 2022, 144, 14042-14046.

Total Synthesis of the Tetracyclic Pyridinium Alkaloid epi-Tetradehydrohalicyclamine B

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Combined C-H Activation/Cope Rearrangement as a Strategic Reaction in Organic Synthesis: Total Synthesis of (-)-Colombiasin A and (-)-Elisapterosin B

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Total Synthesis of the Akuammiline Alkaloid Picrinine

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10-Step Asymmetric Total Synthesis and Stereochemical Elucidation of (+)-Dragmacidin D

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Total Synthesis of Bipolamine I

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TTotal Synthesis of Abyssomicin C and atrop-Abyssomicin C

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Total Synthesis of Dapholdhamine B and Dapholdamine B Lactone

L.-D. Guo, J. Hou, W. Tu, Y. Zhang, Y. Zhang, L. Chen, J. Xu, J. Am. Chem. Soc. 2019, 141, 11613–11720.

Enantioselective Synthesis of (-)-Maoecrystal V by Enantiodetermining C-H Functionalization

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Total Synthesis of Vilmoraconitine

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Total Synthesis of Ginkgolide C and Formal Syntheses of Ginkgolides A and B

M. Hébert, G. Bellavance, L. Barriault, J. Am. Chem. Soc. 2022, 144, 17792-17796.

Total Synthesis of Hirsutellone B

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Total Synthesis of (−)-Daphenylline

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Total Synthesis of Yuzurine-type Alkaloid Daphgraciline

L.-X. Li, L. Min, T.-B. Yao, S.-X. Ji, C. Qiao, P.-L. Tian, J. Sun, C.-C. Li, J. Am. Chem. Soc. 2022, 144, 18823-18828.

Total Synthesis of Puberuline C

T. Shimakawa, S. Nakamura, H. Asai, K. Hagiwara, M. Inoue, J. Am. Chem. Soc. 2023, 145, 600–609.

Enantioselective Total Synthesis of (+)-Aberrarone

W. M. Amberg, E. M. Carreira, J. Am. Chem. Soc. 2022, 144, 15475–15479.

Total Synthesis of the Chlorinated Pentacyclic Indole Alkaloid (+)-Ambiguine G

L. Hu, V. H. Rawal, J. Am. Chem. Soc. 2021, 143, 10872–10875.

Total Synthesis of Farnesin

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Synthetic Studies on Selective, Proapoptotic Isomalabaricane Triterpenoids Aided by Computational Techniques

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Total Synthesis of (-)-Morphine

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An eight-step gram-scale synthesis of (−)-jiadifenolide

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Asymmetric Total Syntheses of Hypoestin A, Albolic Acid, and Ceroplastol II

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Total Synthesis of Carolacton, a Highly Potent Biofilm Inhibitor

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Unified Total Synthesis of Pyrroloazocine Indole Alkaloids Sheds Light on Their Biosynthetic Relationship

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Tandem Decarboxylative Cyclization/Alkenylation Strategy for Total Syntheses of (+)-Longirabdiol, (–)-Longirabdolactone, and (–)-Effusin

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14 Step Synthesis of (+)-Ingenol

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Asymmetric Total Synthesis of Hispidanin A

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Total Synthesis of Rameswaralide Utilizing a Pharmacophore-Directed Retrosynthetic Strategy

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Enantioselective Synthesis of Azamerone

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Enantioselective Total Syntheses of Grayanane Diterpenoids: (−)-Grayanotoxin III, (+)-Principinol E, and (−)-Rhodomollein XX

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Enantioselective Total Synthesis of Cotylenin A

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The Total Synthesis of (−)-Scabrolide A

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The Enantioselective Total Synthesis of Exochomine

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