Assoc.-Prof. Priv.-Doz. M.Sc, Ph.D Petronel Tuluc 

 
 

 
Molecular Endocrinology Group
CavX PhD Program 'Calcium channels in excitable cells'

 

Short CV

 

   Petronel TULUC_2024

 

Contact

Leopold Franzens University of Innsbruck
Institute of Pharmacy - Department for Pharmacology and Toxicology
Center of Chemistry and Biomedicine 
Innrain 80-82, A-6020 Innsbruck, Austria

Phone:   +43-(0) 512-507-58805
E-mail: Petronel.Tuluc@uibk.ac.at

Webpage: https://www.uibk.ac.at/pharmazie/pharmakologie/tuluc-gruppe/tuluc-gruppe.html
Graduate Program: https://cavx.at
Research network: https://www.uibk.ac.at/cmbi/
ORCID No.: 0000-0003-3660-6138

 

Education

2018

“Venia docendi” (Habilitation) in Pharmacology

2004 - 2008

University of Innsbruck, doctoral studies (PhD) in the laboratory of Dr. Bernhard E. Flucher studying the role of Voltage Gated Calcium Channels in health and dissease

2001 - 2003

Master of Science in Medical physics – Biophysics at Alexandru I. Cuza University of Iași, Romania

2001 - 2002

Erasmus scholarship at Institute Européen des Membrane, Montpellier, France studying Plasma Enhanced Chemical Vapour Deposition

1997 - 2001

Bachlor in Physics/Biophysics at Alexandru I. Cuza University of Iași, Romania

Academic career history

2018-presently

Associate Professor, Department of Pharmacology and Toxicology, University of Innsbruck

2013 - 2018

Assistant Professor, Department of Pharmacology and Toxicology, University of Innsbruck

2010 - 2013

Univ. Assistant (postdoc), Department of Pharmacology and Toxicology, University of Innsbruck

2008 - 2010

Principal investigator in MUI research grant MFI 2007-417  (Selbstantrag/Fellowship), Medical University Innsbruck

 Main research areas
  • Role of CaV calcium channels in endocrine cells hormone release. Molecular mechanism of insulin release in health and Diabetes Mellitus.
  • Structure and function of CaV channels and their voltage sensing mechanism.
  • Computer modelling of membrane excitability.
  • Skeletal and cardiac muscle excitation-contraction coupling

Past research funding

2023-2027
(€1.441.421)

FWF doc.funds: CavX PhD programm – Calcium channels in excitable cells (Speaker)

2023-2027
(€191.456)

University of Innbruck Co-Funding for the CavX PhD programm – Calcium channels in excitable cells (Speaker)

2022-2026
(€408.604)

FWF: Role of CaV1.3 Ca2+ channel in pancreatic β-cell function (PI)

2019-2022
(€405.026)

FWF: Mechanisms responsible for sex difference in insulin release (PI)

2018-2022

(EUR 170.670)

FWF doc.funs: CavX PhD programm – Calcium channels in excitable cells (Co-PI)

2014-2016

(EUR 19.804)

Forschungsförderungsmitteln der Nachwuchsförderung 2014 der Universität Innsbruck “ Role of Cav1.3 calcium channel modulation in pancreatic hormones release ” (PI)

2012-2014
(EUR 10.000)

Jubiläumsfonds der Universität Innsbruck “ Role of Cav1.3 calcium channel in pancreatic β-vell survival and insulin release” (PI)

2011-2015

(EUR 399.913)

FWF: “Expression and function of the skeletal muscle calcium channel splice variant CaV1.1-DE29” (CO-PI with B.E. Flucher) 

2008-2010

(EUR 125.923)

Medical University Innsbruck research grant MFI 2007-417, “The role of calcium channel α2δ subunit in native cardiac myocytes” (PI)
  • Total =3.002.147€
  • Own part = 1.657.211€
  

Peer review activities

Ad hoc referee for: Diabetes, Nature Communications, Channels, Biophysical Journal, European Journal of Neuroscience, European Journal of Physiology, Translational Psychiatry, PLOS one, Scientific Reports, Cell Reports, J. Gen. Physiology, Toxicology in Vitro,  Hungarian Scientific Research Fund, Medical Research Fund-UK, Marsden Fund-NZ.

Publications

40 (32 original, 8 reviews/book chapters). Citations 2268, h-index=25, i10 index 32. Full publication list here.

Most relevant publications:

Jacobo-Piqueras, N., Theiner, T., Geisler, S. M. & Tuluc, P. Molecular mechanism responsible for sex differences in electrical activity of mouse pancreatic beta cells. JCI Insight 9, doi:10.1172/jci.insight.171609 (2024) https://www.ncbi.nlm.nih.gov/pubmed/38358819
Ortner, N. J., Sah, A., Paradiso, E., Shin, J., Stojanovic, S., Hammer, N., Haritonova, M., Hofer, N. T., Marcantoni, A., Guarina, L., Tuluc, P., Theiner, T., Pitterl, F., Ebner, K., Oberacher, H., Carbone, E., Stefanova, N., Ferraguti, F., Singewald, N., Roeper, J. & Striessnig, J. The human channel gating-modifying A749G CACNA1D (Cav1.3) variant induces a neurodevelopmental syndrome-like phenotype in mice. JCI Insight 8, doi:10.1172/jci.insight.162100 (2023) https://www.ncbi.nlm.nih.gov/pubmed/37698939
Fernandez-Quintero, M. L., El Ghaleb, Y., Tuluc, P., Campiglio, M., Liedl, K. R. & Flucher, B. E. Structural determinants of voltage-gating properties in calcium channels. Elife 10, doi:10.7554/eLife.64087 (2021) https://www.ncbi.nlm.nih.gov/pubmed/33783354
El Ghaleb, Y., Schneeberger, P. E., Fernandez-Quintero, M. L., Geisler, S. M., Pelizzari, S., Polstra, A. M., van Hagen, J. M., Denecke, J., Campiglio, M., Liedl, K. R., Stevens, C. A., Person, R. E., Rentas, S., Marsh, E. D., Conlin, L. K., Tuluc, P., Kutsche, K. & Flucher, B. E. CACNA1I gain-of-function mutations differentially affect channel gating and cause neurodevelopmental disorders. Brain 144, 2092-2106, doi:10.1093/brain/awab101 (2021) https://www.ncbi.nlm.nih.gov/pubmed/33704440
Hofer, N. T., Tuluc, P., Ortner, N. J., Nikonishyna, Y. V., Fernandes-Quintero, M. L., Liedl, K. R., Flucher, B. E., Cox, H. & Striessnig, J. Biophysical classification of a CACNA1D de novo mutation as a high-risk mutation for a severe neurodevelopmental disorder. Mol Autism 11, 4, doi:10.1186/s13229-019-0310-4 (2020) https://www.ncbi.nlm.nih.gov/pubmed/31921405
Monteleone, S., Lieb, A., Pinggera, A., Negro, G., Fuchs, J. E., Hofer, F., Striessnig, J., Tuluc, P. & Liedl, K. R. Mechanisms Responsible for omega-Pore Currents in Ca(v) Calcium Channel Voltage-Sensing Domains. Biophys J 113, 1485-1495, doi:10.1016/j.bpj.2017.08.010 (2017) https://www.ncbi.nlm.nih.gov/pubmed/28978442
Mastrolia, V., Flucher, S. M., Obermair, G. J., Drach, M., Hofer, H., Renstrom, E., Schwartz, A., Striessnig, J., Flucher, B. E. & Tuluc, P. Loss of alpha(2)delta-1 Calcium Channel Subunit Function Increases the Susceptibility for Diabetes. Diabetes 66, 897-907, doi:10.2337/db16-0336 (2017) https://www.ncbi.nlm.nih.gov/pubmed/28115397
Tuluc, P., Yarov-Yarovoy, V., Benedetti, B. & Flucher, B. E. Molecular Interactions in the Voltage Sensor Controlling Gating Properties of CaV Calcium Channels. Structure 24, 261-271, doi:10.1016/j.str.2015.11.011 (2016) https://www.ncbi.nlm.nih.gov/pubmed/26749442

Ortner, N. J., Bock, G., Vandael, D. H., Mauersberger, R., Draheim, H. J., Gust, R., Carbone, E., Tuluc, P. & Striessnig, J. Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators. Nat Commun 5, 3897, doi:10.1038/ncomms4897 (2014) https://www.ncbi.nlm.nih.gov/pubmed/24941892
Azizan, E. A., Poulsen, H., Tuluc, P., Zhou, J., Clausen, M. V., Lieb, A., Maniero, C., Garg, S., Bochukova, E. G., Zhao, W., Shaikh, L. H., Brighton, C. A., Teo, A. E., Davenport, A. P., Dekkers, T., Tops, B., Kusters, B., Ceral, J., Yeo, G. S., Neogi, S. G., McFarlane, I., Rosenfeld, N., Marass, F., Hadfield, J., Margas, W., Chaggar, K., Solar, M., Deinum, J., Dolphin, A. C., Farooqi, I. S., Striessnig, J., Nissen, P. & Brown, M. J. Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nat Genet 45, 1055-1060, doi:10.1038/ng.2716 (2013) https://www.ncbi.nlm.nih.gov/pubmed/23913004
Tuluc, P., Molenda, N., Schlick, B., Obermair, G. J., Flucher, B. E. & Jurkat-Rott, K. A CaV1.1 Ca2+ channel splice variant with high conductance and voltage-sensitivity alters EC coupling in developing skeletal muscle. Biophys J 96, 35-44, doi:10.1016/j.bpj.2008.09.027 (2009) https://www.ncbi.nlm.nih.gov/pubmed/19134469

Tuluc, P., Kern, G., Obermair, G. J. & Flucher, B. E. Computer modeling of siRNA knockdown effects indicates an essential role of the Ca2+ channel alpha2delta-1 subunit in cardiac excitation-contraction coupling. Proc Natl Acad Sci U S A 104, 11091-11096, doi:10.1073/pnas.0700577104 (2007) https://www.ncbi.nlm.nih.gov/pubmed/17563358

10 most important scientific/scholarly research achievements apart from academic publications
  1. 2001: Erasmus Scholarsip – Montpellier, France
  2. 2007: Molecular Cell Biology and Oncology doctoral program award fellowship
  3. 2008: Research Fellowship of the Medical University of Innsbruck
  4. 2010: Early investigator award from The American Biophysical Society and the Biophysical Society of China
  5. 2013: International calcium channel symposium, Symposium Speaker (March 24-29, Krabi Thailand)
  6. 2018: 3rd European Calcium Channel Conference, Speaker, May 9-12, Alpbach, Austria
  7. 2021: Austrian Neuroscience association meeting, Symposium Speaker, September 28-20, Salzburg, Austria
  8. 2022: 21st International Symposium on Chromaffin cell Biology, Symposium Speaker (7-12 July, Hamburg, Germany)
  9. 2023: Speaker of the FWF-funded CaVX PhD program
  10. International calcium channel meeting, Symposium Speaker (February 25-March 1, Boracay Philippines)
Press releases
  • 2024: Diabetes und Geschlecht DE/EN
  • 2024: Collaboratively exploring vital calcium channels DE/EN
  • 2021: Kalziumkanal: Krankheitsgen für neuronale Entwicklungsstörung EN/DE
  • 2018: Kanalarbeiter im Labor EN/DE

Memberships
  • American Biophysical Society
  • European Association for the Stufy of Diabetes
  • Austrian Biophysical Society
  • Center for Molecular Biosciences Innsbruck

 

 

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