Publications

Rainer Schneider

    1. Klocker H, Schneider R, Burtscher HJ, Auer B, Hirsch-Kauffmann M, Schweiger M. Transient expression of a plasmid gene, a tool to study DNA repair in human cells: Defect of DNA repair in Cockayne syndrome; one thymine cyclobutane dimer is sufficient to block transcription. Eur. J. Cell Biol. 39, 346-351 (1986).

    2. Witkiewicz H, Schneider R, Schweiger M. The F1 gene product of bacterial virus lambda is related to the E.coli chromosomal protein NS2 and is involved in the intracellular DNA organization. Biosci. Rep. 6, 103-111 (1986).

    3. Schweiger M, Auer B, Burtscher HJ, Hirsch-Kauffmann M, Klocker H, Schneider R. DNA repair in human cells: Biochemistry of the hereditary diseases Fanconis anaemia and Cockayne syndrome. 'Fritz-Lipmann Lecture'. Biol. Chem. Hoppe-Seyler 367, 1185-1195 (1986).

    4. Schweiger M, Auer B, Burtscher HJ, Hirsch-Kauffmann M, Klocker H, Schneider R. DNA repair in human cells: Biochemistry of the hereditary diseases Fanconis anaemia and Cockayne syndrome. 'Fritz-Lipmann Lecture'. Eur. J. Biochem. 165, 235-242 (1987).

    5. Schneider R, Auer B, Kühne C, Herzog H, Klocker H, Burtscher HJ, Hirsch-Kauffmann M, Wintersberger U, Schweiger M. Isolation of a cDNA clone for human NAD+: protein ADP-ribosyltransferase. Eur. J. Cell Biol. 44, 302-307 (1987).

    6. Burtscher HJ, Schneider R, Klocker H, Auer B, Hirsch-Kauffmann M, Schweiger M. ADP-ribosyltransferase is highly conserved: Purification and characterization of ADP-ribosyltransferase from a fish and its comparison with the human enzyme. J. Comp. Physiol. B 157, 567-572 (1987).

    7. Burtscher HJ, Klocker H, Schneider R, Auer B, Hirsch-Kauffmann M, Schweiger M. ADP-ribosyltransferase from Helix pomatia: Purification and characterization. Biochem. J. 248, 859-864 (1987).

    8. Golderer G, Schneider R, Auer B, Loidl P, Gröbner P. ADP-ribosylation in isolated nuclei of Physarum polycephalum. Biochem. J. 253, 859-867 (1988).

    9. Schweiger M, Schneider R, Hirsch-Kauffmann M, Auer B, Klocker H, Scherzer E, Thurnher M, Herzog H, Vosberg HP, Wagner EF. DNA-repair in human cells: molecular cloning of cDNA´s coding for enzymes related to repair. In The Roots of Modern Biochemistry (Kleinkauf H, von Döhren H, Jaenicke L, eds), pp. 379-387. Walter de Gruyter, Berlin - New York (1988).

    10. Schneider R, Schneider-Scherzer E, Thurnher M, Auer B, Schweiger M. The primary structure of human ribonuclease/angiogenin inhibitor (RAI) discloses a novel highly diversified protein superfamily with a common repetitive module. EMBO J. 7, 4151-4156 (1988).

    11. Herzog H, Zabel BU, Schneider R, Auer B, Hirsch-Kauffmann M, Schweiger M. Human nuclear NAD+:protein(ADP-ribosyl)transferase: Localisation of the gene on chromosome 1q41-42 and expression of an active human enzyme in Escherichia coli. Proc. Natl. Acad. Sci. USA 86, 3514-3518 (1989).

    12. Auer B, Nagl U, Herzog H, Schneider R, Schweiger M. Human nuclear NAD+ ADP-ribosyltransferase(polymerizing): Organization of the gene. DNA 8, 575-580 (1989).

    13. Schneider R, Eckerskorn C, Lottspeich F, Schweiger M. The human ubiquitin carrier protein E2(Mr=17,000) is homologous to the yeast DNA repair gene RAD6. EMBO J. 9, 1431-1435 (1990).

    14. Herzog H, Höfferer L, Schneider R, Schweiger M. cDNA encoding the human homologue of rat ribosomal protein L35a. Nucleic Acids Res. 18, 4600 (1990).

    15. Hirsch-Kauffmann M, Schwaiger H, Auer B, Schneider R, Herzog H, Klocker H, Schweiger M. Aging and DNA repair. In Molecular Mechanisms of Aging (Beyreuther K, Schettler G, eds), pp. 51-59. Springer, Heidelberg (1990).

    16. Schneider R, Schweiger M. The yeast DNA repair proteins RAD1 and RAD7 share similar putative functional domains. FEBS Lett. 283, 203-206 (1991).

    17. Schneider R, Schweiger M. A novel modular mosaic of cell adhesion motifs in the extracellular domains of the neurogenic trk and trkB tyrosine kinase receptors. Oncogene 6, 1807-1811 (1991).

    18. Schneider R, Higgins MJ, Kieninger D, Schneider-Scherzer E, Hirsch-Kauffmann M, Schweiger M, Eddy RL, Shows TB, Zabel U. The human ribonuclease/angiogenin inhibitor is encoded by a gene mapped to chromosome 11p5.5 within 90kb of the HRAS protooncogene. Cytogenet. Cell Genet. 59, 264-267 (1992).

    19. Schweiger M, Auer B, Herzog H, Hirsch-Kauffmann M, Kaiser P, Flick K, Nagl U, Schneider R. Molecular biology of human nuclear NAD+:ADP-ribosyltransferase (polymerizing). In ADP-Ribosylation Reactions (Poirier GG, Moreau P, eds), pp. 20-29. Springer, New York (1992).

    20. Schneider R, Schweiger M. The yeast RNA1 protein necessary for RNA processing is homologous to the human ribonuclease/angiogenin inhibitor (RAI). Mol. Gen. Genet. 233, 315-318 (1992).

    21. Schneider R. The human protooncogene ret: A communicative cadherin? Trends Biochem. Sci. 17, 468-469 (1992).

    22. Baumgartner M, Schneider R, Auer B, Herzog H, Schweiger M, Hirsch-Kauffmann M. Fluorescence in situ mapping of the human nuclear NAD+ADP-ribosyl-transferase gene and two secondary sites to human chromosomal bands 1q42, 13q34 and 14q24. Cytogenet. Cell. Genet. 61, 172-174 (1992).
        

    23. Flick K, Schneider R, Auer B, Hirsch-Kauffmann M, Schweiger M. No abnormalities in the NAD+ADP-ribosyltransferase (polymerizing) gene of transformed cells from a Fanconi´s anemia patient. Hum. Genet. 89, 690-691 (1992).

    24. Schneider R, Unger G, Stark R, Schneider-Scherzer E, Thiel HJ. Identification of a structural glycoprotein of an RNA virus as a ribonuclease. Science 261, 1169-1171 (1993).

    25. Kofler B, Wallraff E, Herzog H, Schneider R, Auer B, Schweiger M. Purification and characterization of NAD+:ADP-ribosyltransferase(polymerizing) from Dictyostelium discoideum. Biochem. J. 293, 275-281(1993).

    26. Kaiser P, Seufert W, Hoefferer L, Kofler B, Sachsenmaier C, Herzog H, Jentsch S, Schweiger M, Schneider R. A human ubiquitin conjugating enzyme homologous to yeast UBC8. J. Biol. Chem. 269, 8797-8802 (1994).

    27. Oei SL, Herzog H, Hirsch-Kauffmann M, Schneider R, Auer B, Schweiger M. Transcriptional regulation and autoregulation of the human gene for ADP-ribosyltransferase in ADP-ribosylation: Metabolic effects and regulatory functions. Mol. Cell. Biochem. 138, 99-104 (1994).

    28. Kaiser P, Mansour HA, Greeten T, Auer B, Schweiger M, Schneider R. The human ubiquitin-conjugating enzyme UbcH1 is involved in the repair of UV-damaged, alkylated and cross-linked DNA. FEBS Lett. 350, 1-4 (1994).

    29. Windisch JM, Marksteiner R, Schneider R. NGF-binding site mapped to a single leucine-rich motif of TrkA. J. Biol. Chem. 270, 28133-28138 (1995).

    30. Stoiber H, Ebenbichler C, Schneider R, Janatova J, Dierich MP. Interaction of several complement proteins with gp120 and gp41, the two envelope glycoproteins of HIV-1. AIDS 9, 19-26 (1995).

    31. Herzog H, Hort Y, Schneider R, Shine J. Seminalplasmin: recent evolution of another member of the neuropeptide Y gene family. Proc. Natl. Acad. Sci. USA 92, 594-598 (1995).

    32. Digweed M, Günthert U, Schneider R, Seyschab H, Friedl R, Sperling K. Irreversible repression of DNA synthesis in Fanconi anemia cells is alleviated by the product of a novel cyclin-related gene. Mol. Cell. Biol. 15, 305-314 (1995).

    33. Stoiber H, Schneider R, Janatova J, Dierich MP. Human complement proteins C3b, C4b, factor H and properdin react with specific sites in gp120 and gp41, the envelope proteins of HIV1. Immunobiology 193, 98-113 (1995).

    34. Wefes I, Kaiser P, Schneider R, Pickart CM, Finley D. Characterization of a cDNA clone encoding E2-20K, a murine ubiquitin conjugating enzyme. Gene 163, 321-322 (1995).

    35. Kaiser P, Mandl S, Schweiger M, Schneider R. Characterization of functionally independent domains in the human ubiquitin conjugating enzyme UbcH2. FEBS Lett. 377, 193-196 (1995).

    36. Schweiger M, Oei SL, Herzog H, Menardi C, Schneider R, Auer B, Hirsch-Kauffmann M. Regulation of the human poly(ADP-ribosyl)transferase promoter via alternative DNA racket structures. Biochimie 77, 480-485 (1995).

    37. Windisch JM, Marksteiner R, Lang ME, Auer B, Schneider R. Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 bind to a single leucine-rich motif of TrkB. Biochemistry 34, 11256-11263 (1995).

    38. Windisch JM, Auer B, Marksteiner R, Lang ME, Schneider R. Specific neurotrophin binding to leucin-rich motif peptides of TrkA and TrkB. FEBS Lett. 374, 125-129 (1995).

    39. Zhang J, Ziegler M, Schneider R, Klocker H, Auer B, Schweiger M. Identification and purification of a bovine liver mitochondrial NAD+-glycohydrolase. FEBS Lett. 377, 530-543 (1995).

    40. Ziegler M, Jorcke D, Zhang J, Schneider R, Klocker H, Auer B, Schweiger M. Characterization of detergent solubilized beef-liver mitochondrial NAD+ glycohydrolase and its truncated hydrosoluble form. Biochemistry 35, 5207-5212 (1996).

    41. Ebenbichler CF, Stoiber H, Schneider R, Patsch JR, Dierich MP. The immunodeficiency virus Type 1 transmembrane gp41 protein is a calcium-binding protein and interacts with the putative second receptor molecules in a calcium dependent manner. J. Virol. 70, 1723-1728 (1996).

    42. Windisch JM, Schneider R, Stark R, Weiland E, Thiel JH. Ribonuclease of classical swine fever virus: Biochemical characterization and inhibition by virus-neutralizing monoclonal antibodies. J. Virol. 70, 352-358 (1996).

    43. Nuber U, Schwarz S, Kaiser P, Schneider R, Scheffner M. Cloning of human ubiquitin conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5. J. Biol. Chem. 271, 2795-2800 (1996).

    44. Menardi C, Schneider R, Kaspar F, Klocker H, Hirsch-Kauffmann M, Auer B, Schweiger M. Identification of a splice-site mutation in a patient with complete deficiency of adenine phosphoribosyltransferase (APRT). Hum. Mutat. 10, 251-255 (1997).

    45. Stoiber H, Frank I, Spruth M, Schwendinger M, Mullauer B, Windisch JM, Schneider R, Katinger H, Ando I, Dierich MP. Inhibition of HIV-1 infection in vitro by monoclonal antibodies to the complement receptor type 3 (CR3): an accessory role for CR3 during virus entry? Mol. Immunol. 34, 855-863 (1997).

    46. Kadari A, Windisch JM, Ebendal T, Schneider R, Humpel C. Cell death of adult CA1 neurons after intraventricular injection of a novel peptide derived from trkA. J. Neurosci. Res. 50, 402-412 (1997).

    47. Schneider R, Windisch JM. Brain-derived neurotrophic factor. In Human Cytokines, Handbook of Basic and Clinical Research, Vol. 3 (Aggarwal BB, ed), pp. 400-435. Blackwell, Oxford (1998).

    48. Tiefenthaler M, Marksteiner R, Neyer S, Koch F, Hofer S, Schuler G, Nussenzweig M, Schneider R, Heufler C. M1204, a novel 2',5' oligoadenylate synthetase with a ubiquitin-like extension, is induced during maturation of murine dendritic cells. J. Immunol. 163, 760-765 (1999).

    49. Thumb W, Graf C, Parslow T, Schneider R, Auer M. Temperature inducible beta-sheet structure in the transactivation domains of retroviral regulatory proteins of the Rev family. Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. 55, 2729-2743 (1999).

    50. Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ. Ubiquitination of a new form of alpha-synuclein by parkin from human brain: Implications for Parkinson's disease. Science 293, 263-9 (2001).

    51. Trockenbacher A, Suckow V, Foerster J, Winter J, Krauss S, Ropers HH, Schneider R, Schweiger S. MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation. Nature Genet. 29, 287-294 (2001).

    52. Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ. Ubiquitination of a new form of alpha-synuclein by parkin. In Mapping the Progress of Alzheimer´s and Parkinson´s Disease, Advances in Behavioral Biology, Vol 51 (Mizuno Y, Fisher A, Hamin J., eds), pp 301-304. Kluwer/Plenum, New York (2002).

    53. Schweiger S, Schneider R. The MID1/PP2A complex: a key to the pathogenesis of Opitz BBB/G syndrome. Bioessays 25, 356-366 (2003).

    54. Boehm T, Hofer S, Winklehner P, Kellersch B, Geiger C, Trockenbacher A, Neyer S, Fiegl H, Ebner S, Ivarsson L, Schneider R, Kremmer E, Heufler C, Kolanus W. Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration. EMBO J. 22, 1014-1024 (2003).

    55. Winter J, Lehmann T, Krauss S, Trockenbacher A, Kijas Z, Foerster J, Suckow V, Yaspo M-L, Kulozik A, Kalscheuer V, Schneider R, Schweiger S. Regulation of the MID1 protein function is fine tuned by a complex pattern of alternative splicing. Hum. Genet. 114, 541-552 (2004).

    56. Santic R, Fenninger K, Graf K, Schneider R, Hauser-Kronberger C, Schilling FH, Kogner P, Ratschek M, Jones N, Sperl W, Kofler B. Gangliocytes in neuroblastic tumors express alarin: a novel peptide derived by differential splicing of the galanin-like peptide gene. J. Mol. Neurosci. 29, 145-152 (2006).

    57. Winter J, Kunath M, Roepcke S, Krause S, Schneider R, Schweiger S. Alternative polyadenylation signals and promoters act in concert to control tissue-specific expression of the Opitz Syndrome gene MID1. BMC Mol. Biol. 8:105 (2007).

    58. Aranda-Orgilles B, Trockenbacher A, Winter J, Aigner J, Köhler A, Jastrzebska E, Stahl J, Müller EC, Otto A, Wanker EE, Schneider R, Schweiger S. The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex. Hum. Genet. 123, 163-176 (2008).

    59. Krauss S, Foerster J, Schneider R, Schweiger S. PP2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3. Cancer Res. 68, 4658-4665 (2008).

    60. Achmüller C, Köhler A, Bösch S, Schneider R. A-overhang-dependent repeat expansion determination (ADRED). Biotechniques 45, 577-580 (2008).

    61. Aranda-Orgilles B, Aigner J, Kunath M, Lurz R, Schneider R, Schweiger S. Active transport of the ubiquitin ligase MID1 along the microtubules is regulated by protein phosphatase 2A. PLoS ONE 3, e3507 (2008).

    62. Hering S, Achmüller C, Köhler A, Poewe W, Schneider R, Boesch SM. Phenotype variability in spinocerebellar ataxia type 2: A longitudinal family survey and a case featuring an unususal benign course of disease. Mov. Disord. 24, 774-777 (2009).

    63. Paal M, Heel T, Schneider R, Auer B. A novel Ecotin-Ubiquitin-Tag (ECUT) for efficient, soluble peptide production in the periplasm of Escherichia coli. Microb. Cell Fact. 8:7 (2009).

    64. Gruber T, Hermann-Kleiter N, Hinterleitner R, Fresser F, Schneider R, Gastl G, Penninger JM, Baier G. PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation. Sci. Signal. 2 (76), ra30 (2009).

    65. Krauß S, So J, Hambrock M, Köhler A, Kunath M, Scharff C, Wessling M, Grzeschik K-H, Schneider R, Schweiger S. Point mutations in GLI3 lead to misregulation of its subcellular localization. PLoS ONE 4, e7471 (2009).

    66. Kickstein E, Krauss S, Thornhill P, Rutschow D, Zeller R, Sharkey R, Williamson R, Fuchs M, Köhler A, Glossmann H, Schneider R, Sutherland C, Schweiger S. Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling. Proc. Natl. Acad. Sci. USA 107, 21830-21835 (2010).

    67. Heel T, Paal M, Schneider R, Auer B. Dissection of an old protein reveals a novel application: domain D of Staphylococcus aureus Protein A (sSpAD) as a secretion-tag. Microb. Cell Fact. 9, 92 (2010).

    68. Boesch S, Sturm B, Nachbauer W, Hering S, Steinkellner H, Schneider R, Poewe W, Scheiber-Mojdehkar B. Review: Friedrich Ataxia and Erythropoietin. The Open Drug Discovery Journal 2, 18-24 (2010).

    69. Aranda-Orgilles B, Rutschow D, Zeller R, Karagiannidis AI, Köhler A, Chen C, Wilson T, Krause S, Roepcke S, Lilley D, Schneider R, Schweiger S. The PP2a-Specific Ubiquitin Ligase MID1 is a Sequence-Dependent Regulator of Translation Efficiency Controlling 3-Phosphoinositide Dependent Protein Kinase-1 (PDPK-1). J. Biol. Chem. 286, 39945-39957 (2011).

    70. Bernhard Auer, Rainer Schneider, Thomas Heel, Michael Sponring, Maria Koll, Sabrina Schindler, Thomas Zögg, Hans Brandstetter. Npro autoprotease fusion technology (NAFT), a platform for industrial peptide/protein production in E. coli. New Biotechnology 29:S240 (2012).

    71. Krauß S, Griesche N, Jastrzebska E, Chen C, Rutschow D, Achmüller C, Dorn S, Boesch SM, Lalowski M, Wanker E, Schneider R, Schweiger S. Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex. Nat. Commun. 4, 1511 (2013).

    72. Heel T, Vogel GF, Lammirato A, Schneider R, Auer B. FlgM as a Secretion Moiety for the Development of an Inducible Type III Secretion System.  PLoS ONE 8, e59034 (2013).

    73. Zögg T, Sponring M, Schindler S, Koll M, Schneider R, Brandstetter H, Auer B. Crystal Structures of the Viral Protease Npro Imply Distinct Roles for the Catalytic Water in Catalysis. Structure 21, 1-10 (2013).
       
    74. Eigentler A, Boesch S, Schneider R, Dechant G, Nat R. Induced Pluripotent Stem Cells from Friedreich Ataxia Patients Fail to Up-regulate Frataxin during in vitro Differentiation to Peripheral Sensory Neurons. Stem Cells Dev. 22, 3271-82 (2013).
       
    75. Nachbauer W, Boesch S, Schneider R, Eigentler A, Wanschitz J, Poewe W, Schocke M. Bioenergetics of the Calf Muscle in Friedreich Ataxia Patients Measured by 31P-MRS Before and After Treatment with Recombinant Human Erythropoietin. PLoS One 8, e69229 (2013).

    76. Demir U, Koehler A, Schneider R, Schweiger S, Klocker H. Metformin anti-tumor effect via disruption of the MID1 translational regulator complex and AR downregulation in prostate cancer cells. BMC Cancer 14:52 (2014).

    77. Nachbauer W, Nocker M, Karner E, Stankovic I, Unterberger I, Eigentler A, Schneider R, Poewe W, Delazer M, Boesch S. Episodic ataxia type 2: phenotype characteristics of a novel CACNA1A mutation and review of the literature. J. Neurol., 983-991 (2014).

    78. Köhler A, Demir U, Kickstein E, Krauss S, Aigner J, Aranda-Orgillés B, Karagiannidis AI, Achmüller C, Bu H, Wunderlich A, Schweiger MR, Schaefer G, Schweiger S, Klocker H, Schneider R. A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signaling. Mol. Cancer, 13:146 (2014).

    79. Schweiger S, Dorn S, Fuchs M, Köhler A, Matthes F, Müller EC, Wanker E, Schneider R Krauß S.The E3-ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu. J. Biol. Chem. 289, 31805-31817 (2014).

    80. Schindler S, Missbichler B, Walther C, Sponring M, Cserjan-Puschmann M, Auer B, Schneider R, Dürauer A. Npro fusion technology: On-column complementation to improve efficiency in biopharmaceutical production. Protein Expression and Purification 120, 42-50 (2016).

    81. Lemmermeyer T, Lamp B, Schneider R, Ziebuhr J, Tekes G, Thiel H-J. Characterization of monoclonal antibodies against feline coronavirus accessory protein 7b. Veterinary Microbiology 184, 11-19 (2016).

    82. Schweiger S, Matthes F, Posey K, Kickstein E, Weber S, Hettich MM, Pfurtscheller S, Ehninger D, Schneider R, Krauß S. Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex. Scientific Reports 7, 13753 (2017).

    83. Hartl M, Schneider R. A unique family of neuronal signaling proteins implicated in oncogenesis and tumor suppression. Front. Oncol.  9:289 (2019).

    84. Mayrhofer Johanna, Enzler Florian, Feichtner Andreas, Röck Ruth, Fleischmann Jakob, Raffeiner Andrea, Tschaikner Philipp, Ogris Egon, Huber Roland, Hartl Markus, Schneider Rainer, Troppmair Jakob, Torres-Quesada Omar, Stefan Eduard. Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies. Proc Natl Acad Sci U S A 117, 31105-31113 (2020).

    85. Florian Enzler, Philipp Tschaikner, Rainer Schneider, Eduard Stefan. KinCon: Cell-based recording of full-length kinase conformations. IUBMB-LIFE (2020).

    86. Öhlknecht Christoph, Petrov Drazen, Engele Petra, Kröß Christina, Sprenger Bernhard, Fischer Andreas, Lingg Nico, Schneider Rainer, Oostenbrink Chris. Enhancing the promiscuity of a member of the Caspase protease family by rational design. Proteins 88, 1303-1318 (2020).

    87. Cserjan-Puschmann Monika, Lingg Nico, Engele Petra, Kröß Christina, Loibl Julian, Fischer Andreas, Bacher Florian, Frank Anna-Carina, Öhlknecht Christoph, Brocard Cécile, Oostenbrink Chris, Berkemeyer Matthias, Schneider Rainer, Striedner Gerald, Jungbauer Alois. Production of Circularly Permuted Caspase-2 for Affinity Fusion-Tag Removal: Cloning, Expression in Escherichia coli, Purification, and Characterization. Biomolecules 10:1592 (2020).

    88. Mödlhammer A, Pfurtscheller S, Feichtner A, Hartl M, Schneider R. The diarylheptanoid curcumin induces MYC inhibition and cross-links this oncoprotein to the coactivator TRRAP.  Front. Oncol. 11:660481 (2021).

    89. Kröß C, Engele P, Sprenger B, Fischer A, Lingg N, Baier M, Öhlknecht C, Lier B, Oostenbrink Chris, Cserjan-Puschmann M, Striedner G, Jungbauer A, Schneider R. PROFICS: A bacterial selection system for directed evolution of proteases. J Biol Chem 297(4):101095 (2021).

    90. Öhlknecht Christoph, Katz Sonja, Kröß Christina, Sprenger Bernhard, Engele Petra, Schneider Rainer, Oostenbrink Chris. Efficient In Silico Saturation Mutagenesis of a Member of the Caspase Protease Family. J Chem Inf Model 61, 1193-1203 (2021).

    91. Lingg Nico, Cserjan-Puschmann Monika, Fischer Andreas, Engele Petra, Kröß Christina, Schneider Rainer, Brocard Cécile, Berkemeyer Matthias, Striedner Gerald, Jungbauer Alois. Advanced purification platform using circularly permuted caspase-2 for affinity fusion-tag removal to produce native fibroblast growth factor 2. Journal of Chemical Technology and Biotechnology (2021).

    92. Köppl, Christoph; Lingg, Nico; Fischer, Andreas; Kröß, Christina; Loibl, Julian; Buchinger, Wolfgang; Schneider, Rainer; Jungbauer, Alois; Striedner, Gerald; Cserjan-Puschmann, Monika. Fusion Tag Design Influences Soluble Recombinant Protein Production in Escherichia coli. International Journal of Molecular Sciences 23/14, S. 7678 (2022).

    93. Lingg, Nico; Kröß, Christina; Engele, Petra; Öhlknecht, Christoph; Köppl, Christoph; Fischer, Andreas; Lier, Bettina; Loibl, Julian; Sprenger, Bernhard; Liu, Jakob; Scheidl, Patrick; Berkemeyer, Matthias; Buchinger, Wolfgang; Brocard, Cécile; Striedner, Gerald; Oostenbrink, Chris; Schneider, Rainer; Jungbauer, Alois; Cserjan-Puschmann, Monika. CASPON platform technology: Ultrafast circularly permuted caspase-2 cleaves tagged fusion proteins before all 20 natural amino acids at the N-terminus. New Biotechnology  71, S. 37 - 46 (2022).

    94. Indelicato, Elisabetta; Kirchmair, Alexander; Amprosi, Matthias; Steixner, Stephan; Nachbauer, Wolfgang; Eigentler, Andreas;  Wahl, Nico; Apostolova, Galina;  Krogsdam, Anne; Schneider, Rainer; Wanschitz, Julia; Trajanoski, Zlatko;  Boesch, Sylvia. Skeletal muscle transcriptomics dissects the pathogenesis of Friedreich’s ataxia. Human Molecular Genetics 32, 2241-2250 (2023).

    95. Costacurta, Francesco; Dodaro, Andrea; Bante, David; Schöppe, Helge; Sprenger, Bernhard; Moghadasi, Seyed Arad; Fleischmann, Jakob; Pavan, Matteo; Bassani, Davide; Menin, Silvia; Rauch, Stefanie; Krismer, Laura; Sauerwein, Anna; Heberle, Anne; Rabensteiner, Toni; Ho, Joses; Harris, Reuben S; Stefan, Eduard; Schneider, Rainer; Kaserer, Teresa; Moro, Stefano; von Laer, Dorothee; Heilmann, Emmanuel. A comprehensive study of SARS-CoV-2 main protease (Mpro) inhibitor-resistant mutants selected in a VSV-based system. bioRxiv 09.22.558628 (2023).

    96. Indelicato, Elisabetta; Faserl, Klaus; Amprosi, Matthias; Nachbauer, Wolfgang; Schneider, Rainer; Wanschitz, Julia; Sarg, Bettina; Boesch, Sylvia. Skeletal muscle proteome analysis underpins multifaceted mitochondrial dysfunction in Friedreich's ataxia. Front. Neurosci. 17:1289027 eCollection (2023).

 

 

Nach oben scrollen