Dr. rer. nat. Dipl.-Pharm. Solveigh Koeberle
Michael Popp Institute
University of Innsbruck
Mitterweg 24, A-6020 Innsbruck, Austria
Phone: +43 512 507 – 57913
E-Mail: solveigh.koeberle@uibk.ac.at
Research
Ferroptosis-modulating natural products and their mode of action: Targeting Redox Signaling
X Messenger
Follow my latest news on
https://x.com/skoeberle9?t=UhaLNizEAgbMYz3J2f3xdw&s=09
Curriculum vitae
Since April 2022
Principal investigator at the Michael Popp Institute, University of Innsbruck (Austria)
Since October 2022
Interim professor for the Chair in Medicinal Chemistry I, University of Regensburg (Germany)
2019-2022
Senior Lecturer at the Unit Pharmacognosy, University of Innsbruck (Austria)
2017-2019
Postdoc at the Department of Molecular Nutritional Science, University of Jena (Germany)
2011-2017
Postdoc at the Leibniz-Institute on Aging, Fritz Lipmann Institute e.V., Jena (Germany)
2009-2011
Postdoc at the Department of Cellular Neurobiology, The University of Tokyo (Japan)
2006-2009
Ph.D. in “Medicinal Chemistry” at the Department of Medicinal/Pharmaceutical Chemistry, University of Tübingen (Germany)
2000-2005
Education as pharmacist and diploma pharmacist at the University of Tübingen (Germany)
Publications
- Koeberle SC*, Kipp AP, Stuppner H, Koeberle A* (2023) Ferroptosis-modulating small molecules for targeting drug-resistant cancer: Challenges and opportunities in manipulating redox signaling. Med Res Rev, DOI: 10.1002/med.21933. * Corresponding Author
- Wolfram T, Weidenbach, LM, Adolf J., Schwarz, M., Schädel P, Gollowitzer A, Werz O, Koeberle A, Kipp A and Koeberle SC* (2021) The trace element selenium is important for redox signaling in phorbol ester differentiated THP-1 macrophages. Int J Mol Sci. DOI: 3390/ijms222011060. * Corresponding Author
- Koeberle SC, Gollowitzer A, Laoukili J, Kranenburg O, Werz O, Koeberle A and Kipp AP (2020) Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-κB-driven inflammation through redox-active mechanisms. Redox Biol. DOI: 10.1016/j.redox.2019.101388.
- Koeberle SC, Kipp AP (2018). Selenium and inflammatory mediators. In: ‘Selenium’, Bernhard Michalke (Ed.) Molecular and Integrative Toxicology. DOI: 10.1007/978-3-319-95390-8_7. INVITED REVIEW/BOOK CHAPTER
- Bertz, M, Kühn, K, Koeberle, SC, Müller, MF, Hoelzer, D, Thies, K, Deubel, S, Thierbach, R, Kipp, AP (2018) Selenoprotein H controls cell cycle progression and proliferation of human colorectal cancer cells. Free Radic Biol Med. DOI: 10.1016/j.freeradbiomed.2018.01.010.
- Koeberle SC, Shinji T, Kuriu, T, Iwasaki H, Koeberle A, Schulz A, Helbing D, Yamagata Y, Morrison H, Okabe S (2017) Developmental stage-dependent regulation of spine formation by calcium calmodulin dependent protein kinase IIα and Rap1. Sci Rep. DOI: 10.1038/s41598-017-13728-y.
- Pein H, Koeberle SC*, Voelkel M, Schneider F, Rossi A, Loeser K, Sautebin L, Morrison H, Werz O, Koeberle A (2017) Vitamin A regulates Akt signaling through the phospholipid fatty acid composition. FASEB J (IF: 5.5). *shared first authorship. DOI: 10.1096/fj.201700078R.
- Koeberle A, Pergola C, Shindou H, Koeberle SC, Shimizu T, Laufer SA, Werz O (2015) Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with ER homeostasis. FASEB J, 29, 2439-2449. DOI: 1096/fj.14-268474.
- Koeberle A, Shindou H, Koeberle SC, Laufer SA, Shimizu T, Werz O (2013) Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding. PNAS, 110 (7), 2546-2551 (IF: 10.7)
- Fischer S, Wentsch HK, Mayer-Wrangowski SC, Zimmermann M, Bauer SM, Storch K, Niess R, Koeberle SC, Grütter C, Boeckler FM, Rauh D, Laufer SA (2013) Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity. J Med Chem, 56 (1), 241-253 (IF: 5.5).
- Koeberle SC, Fischer S, Schollmeyer D, Schattel V, Grütter C, Rauh D, Laufer SA (2012) Design, synthesis, and biological evaluation of novel disubstituted dibenzosuberones as highly potent and selective inhibitors of p38 mitogen activated protein kinase. J Med Chem, 55 (12), 5868-5877 (IF: 5.4).
- Koeberle SC, Romir J, Fischer S, Koeberle A, Schattel V, Albrecht W, Grütter C, Werz O, Rauh D, Stehle T, Laufer SA (2011) Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. Nat Chem Biol, 8, 141-3 (IF: 16.1).
- Fischer S, Koeberle SC, Laufer SA (2011) p38α mitogen-activated protein kinase inhibitors, a patent review (2005-2011). Expert Opin Ther Pat, 21, 1843-66 (IF: 2.1).
- Karcher SC and Laufer, SA (2009) Successful structure-based design of recent p38 MAP kinase inhibitors. Curr Top Med Chem, 9, 655-676 (IF: 4.3).
- Karcher SC and Laufer SA (2009) Aza-analogue dibenzepinone scaffolds as p38 MAP kinase inhibitors: Design, synthesis and biological data of inhibitors with improved physico¬chemical properties. J Med Chem, 52, 1778-1782 (IF: 5.2).
- Laufer SA, Ahrens GM, Karcher SC, Hering JS, Niess R. (2006) Design, synthesis, and biological evaluation of phenylamino-substituted 6,11-dihydro-dibenzo[b,e]oxepin-11-ones and dibenzo[a,d]cycloheptan-5-ones: Novel p38 MAP kinase inhibitors. J Med Chem, 49 (26), 7912-7915 (IF: 5.1)
Awards, fellowships and fundings
| 2022 | ICTEM Travel Award, International Conference of Trace Elements and Minerals 2022 in Aachen (Germany) |
| 2019-2021 |
Grant of the Friedrich-Schiller University of Jena (Germany) |
| 2016-2017 | Fellowship of the Leibniz Institute on Aging Jena (Germany) |
| 2014-2015 | Fellowship of the Leibniz Institute on Aging Jena (Germany) |
| 2009-2011 | Fellowship of the „Deutsche Pharmazeutische Gesellschaft“(DPhG) / Pharmaceutical Society of Japan (PSJ) and of the Takeda Science Foundation for a 2-year research period at The University of Tokyo (Japan) |
| 2005 | Participation at the “55th meeting of Nobel laureates in Medicine, Chemistry, and Physics in Lindau” (Germany) |
Memberships
| Since 2004 | Member of the German Pharmaceutical Society (DPhG) |
| Since 2009 | Member of the Takeda Science Foundation |
| 2010 | Member of the “Japanese Society of Neuroscience” |
| Since 2018 | Member of the Society of Minerals and Trace Elements (GMS) |
| Since 2020 | Member of the Herbal Medicinal Products Platform Austria (HMPPA) |
| Since 2024 | Member of the Society of Medicinal Plant and Natural Product Research |
Oral Presentations
| 2023 | Oral presentation at the Seminar "Current Discoveries in Biomedical Research" (Innsbruck, Austria) 2023 |
| 2023 | Oral presentation at the Annual DPhG Annual Meeting 2023 (Tübingen, Germany) |
| 2023 | Oral presentation at the EMBO Workshop Ferroptosis: When metabolism meets cell death (Seeon- Seebruck, Germany) |
| 2022 | Oral presentation at the CMBI (Center for Molecular Biosciences Innsbruck) Meeting 2022 (Igls, Austria) |
| 2022 | INVITED TALK, Mini-Symposium: Michael Popp Institute, University of Innsbruck - German Cancer Research Center, Heidelberg. Cell death: metabolism, bioactive lipids and therapeutic strategies (VIRTUAL) |
| 2022 | INVITED TALK at the ICTEM (International Conference of Trace Elements and Minerals 2022 (Aachen, Germany) |
| 2021 | INVITED TALK at the HMPPA Symposium Milk Thistle: Phytochemical, pharmacological and clinical evidence (VIRTUAL) |
| 2021 | Highlight Talk at the Annual DPhG Annual Meeting 2021 (VIRTUAL) |
| 2021 | Presentation at the HMPPA Symposium “Next Generation in Pharmacognosy” 2021 (Krems, Austria) |
| 2021 | Highlight Talk at the EUFEPS (Meeting of the European Federation of Pharmaceutical Science) 2021 (VIRTUAL) |
| 2021 | Highlight Talk at the Meeting Frontiers in Medicinal Chemistry 2021 (VIRTUAL) |
| 2021 | Oral presentation at the 58. Scientific Congress of the DGE (German Society of Nutrition) 2020 (VIRTUAL) |
| 2020 | Oral presentation at the Seminar “Current research results in Pharmacy“ (Innsbruck, Austria) 2021 (VIRTUAL) |
| 2012 | Oral presentation for the Evaluation of the Leibniz Institute on Aging Jena (Jena, Germany) |
| 2011 |
Oral presentation at the Leibniz Institute on Aging Jena (Jena, Germany) |
| 2010 |
Oral presentation at the Joint Workshop, The University of Tokyo (Tokyo, Japan) |
| 2009 |
Oral presentation at the University of Tübingen (Tübingen, Germany) |
| 2005 | Oral presentation at the University of Tübingen (Tübingen, Germany) |
Peer review activities
- Nature (IF 64.8)
- Cancer Communications (IF 16.8)
- Theranostics (IF 12.4)
- British Journal of Pharmacology (IF 8.7)
- International Journal of Molecular Science (IF 6.2)
- Food and Chemical Toxicology (IF 5.6)
- BioMed Research International (IF 3.4)
Public Relation Work
| 2021 |
Contribution to the reorganization of the sector “Medicinal Plants” and “Agricultural Plants” of the Botanical Garden in Innsbruck |